4-imidomethyl-1-¬2'phenyl-2'oxoethyl-|piperidines as...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/06 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2134077

The present invention is directed to a new class of serotonin 5HT2 antagonists of formula (I) and their use in the treatment of a variety of diseases, in which R is represented by hydrogen, halog- en, C1-4 alkyl, C1-4 alkoxy, -CF3, -OH, or -COF3; and A is repre- sented by one of the following imide derivatives in which R1 and R2 are each independently represented by (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, -CF3, -OH, or -OCF3; and the pharmaceutically acceptable salts there- of.

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