4-isopropylphenyl glucitol compounds as sgltl inhibitors

Details 4-isopropylphenyl glucitol compounds as sgltl inhibitors 4-isopropylphenyl glucitol compounds as sgltl inhibitors

C - Chemistry, Metallurgy

07

D

C07D 309/10 (2006.01) A61K 31/351 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2752212

The present invention provides 4-isopropylphenyl glucitol compounds which have no tendency to accumulate in the body and which inhibit SGLT1 activity to suppress postprandial hyperglycemia (or impaired glucose tolerance) through suppression of glucose absorption in the small intestine, whereby the compounds, for example, can suppress the onset of diabetes and metabolic syndrome or can treat these diseases. A 4-isopropylphenyl glucitol compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: [Chem. 1] wherein R1 represents a hydrogen atom, etc., R2 represents a methyl group, etc., R3 represents a C1-4 alkyl group substituted with an amino group(s), etc., and R4 represents a hydrogen atom, etc.

La présente invention concerne des composés de 4-isopropylphényl glucitol qui ne présentent aucune tendance à s'accumuler dans le corps et qui inhibent l'activité de SGLT1 pour supprimer l'hyperglycémie postprandiale (ou altération de la tolérance au glucose) par le biais de la suppression de l'absorption du glucose dans le petit intestin, les composés, par exemple, pouvant supprimer le déclenchement d'un diabète ou d'un syndrome métabolique ou pouvant traiter ces maladies. L'invention concerne un composé de 4-isopropylphényl glucitol représenté par la formule (I) suivante ou son sel pharmaceutiquement acceptable : [Chem. 1] où R1 représente un atome d'hydrogène, etc., R2 représente un groupe méthyle, etc., R3 représente un groupe alkyle ne C1-4 substitué par un/des groupe(s) amino, etc., et R4 représente un atome d'hydrogène, etc.

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