4-methoxymethyl-pyrrolidine-2-carboxylic acid compounds and...

Details 4-methoxymethyl-pyrrolidine-2-carboxylic acid compounds and... 4-methoxymethyl-pyrrolidine-2-carboxylic acid compounds and...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/427 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2585170

Anti-viral agents of Formula (la) wherein: A represents hydroxy; D represents 4-tert-butyl-3-methoxyphenyl; E represents 1,3-~thiazol-2-yl or 5-methyl-1,3- thiazol-2-yl; G represents methoxymethyl; J represents 1,3~ thiazol-2- ylmethyl, 1,3-thiazol-4-ylmethyl, 1,2-thiazol-3-ylmethyl, or 1H-pyrazol-1- ylmethyl; and salts, solvates and esters thereof; provided that when A is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert- butyl;processes for their preparation and their use in HCV treatment are provided.

L'invention concerne des agents antiviraux de formule (Ia), dans laquelle A représente hydroxy, D représente 4-tert-butyl-3-méthoxyphényle, E représente 1,3-thiazol-2-yle ou 5-méthyl-1,3-thiazol-2-yle, G représente méthoxyméthyle, et J représente 1,3-thiazol-2-ylméthyle, 1,3-thiazol-4-ylméthyle, 1,2-thiazol-3-ylméthyle ou 1H-pyrazol-1-ylméthyle, ainsi que des sels, des solvates et des esters de ces composés, à condition que, lorsque A est estérifié pour former OR, où R est choisi parmi alkyle, aralkyle, aryloxyalkyle ou aryle à chaîne droite ou ramifiée, R soit autre que tert-butyle. L'invention concerne également des procédés pour leur préparation et leur utilisation dans le traitement du VHC.

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