4-(methyl sulfonyl amino) phenyl analogues as vanilloid...

Details 4-(methyl sulfonyl amino) phenyl analogues as vanilloid... 4-(methyl sulfonyl amino) phenyl analogues as vanilloid...

C - Chemistry, Metallurgy

07

C

C07C 311/08 (2006.01)

Patent

CA 2533547

The present invention relates to novel 4-(methylsulfonylamino) phenyl analogue as a potent vanilloid receptor antagonist and the pharmaceutical compositions comprising the same. The inventive compound can be useful for analgesics to prevent, alleviate or treat pain diseases or inflammatory disease comprising pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease and urgent urinary incontinence.

L'invention concerne un nouvel analogue de 4-(méthylsulfonylamino)phényle utilisé en tant qu'antagoniste puissant du récepteur vanilloïde, ainsi que la composition pharmaceutique comprenant ledit analogue. Le composé de l'invention peut être utile pour des agents analgésiques pour prévenir, atténuer ou traiter les algies ou les maladies inflammatoires, dont la douleur, la douleur aiguë, la douleur chronique, la douleur neuropathique, la douleur post-opératoire, la migraine, l'arthralgie, les neuropathies, la lésion nerveuse, la neuropathie diabétique, la neurodégénérescence, les affections cutanées névrotiques, l'accident vasculaire cérébral, l'hypersensibilité de la vessie, le syndrome du côlon irritable, un trouble respiratoire, tel que l'asthme ou la maladie obstructive respiratoire, l'irritation cutanée, de membrane de l'oeil ou de la muqueuse et de la muqueuse, l'hyperthermie, l'ulcère de l'estomac-duodénal, la maladie intestinal inflammatoire, la maladie inflammatoire et la miction urgente.

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