4-n-acyl, 2'-n-acyl and 4,2'-n,n-diacyl fortimicin e...

Details 4-n-acyl, 2'-n-acyl and 4,2'-n,n-diacyl fortimicin e... 4-n-acyl, 2'-n-acyl and 4,2'-n,n-diacyl fortimicin e...

C - Chemistry, Metallurgy

07

H

260/300, 260/358

C07H 15/22 (2006.01) C07H 15/224 (2006.01)

Patent

CA 1128535

4-N-ACYL, 2'-N-ACYL AND 4, 2'-N, N'-DIACYLFORTIMICIN E DERIVATIVES . Abstract 4-N-Acyl, 2'-N-acyl and 4, 2'-N, N'-diacylfortimicin derivatives represented by the formula Image wherein R is hydrogen, acyl, aminoacyl, N-lower alkylamino acyl, N, N-diloweralkylamlnoacyl, hydroxy-substituted aminoacyl or an amino acid residue; R1 is hydrogen, acyl, aminoacyl, N-loweralkylaminoacyl, N, N-dilower- alkylaminoacyl, hydroxy-substituted aminoacyl or an amino acid residue, with the limitation that R cannot be hydrogen when R1 is hydrogen, and P cannot be hydrogen ehen R is hydrogen; the pharmaceutically acceptable salts thereof: intermediates therefor; pharmaceutical compositions; and methods of making and usinq the compounds.

314133

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