4-n-acylfortimicin b derivatives and the chemical conversion...

Details 4-n-acylfortimicin b derivatives and the chemical conversion... 4-n-acylfortimicin b derivatives and the chemical conversion...

C - Chemistry, Metallurgy

07

H

260/305, 530/7.0

C07H 15/22 (2006.01) C07H 15/224 (2006.01)

Patent

CA 1114809

Abstract of the Disclosure This invention provides 4-N-acylfortimicin B derivatives of the structure Image wherein R is acyl, aminoacyl, N-momoloweralkylaminoacyl, N,N-dilowaralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula -?-CH2NHR1 where R1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof. The compounds are useful as intermediates for preparing 4-N-alkyl or substituted alkylfortimicin B derivatives. In addition to their utility as intermediates, some of the compounds of this invention are also useful as antimicrobial agents. -1-

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