4-(naphthalenyloxy)piperidine derivatives

Details 4-(naphthalenyloxy)piperidine derivatives 4-(naphthalenyloxy)piperidine derivatives

C - Chemistry, Metallurgy

07

D

260/292.6

C07D 211/46 (2006.01)

Patent

CA 1123440

M-1031 4-(NAPHTHALENYLOXY)PIPERIDINE DERIVATIVES ABSTRACT OF THE DISCLOSURE Novel compounds of the formula Image wherein n is an integer of from 2 to 5, R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl, R1 is hydrogen, alkyl, alkoxy or halogen, and Z is carbonyl or hydroxy- methylene and their pharmaceutically acceptable acid addition salts are useful as antipsychotic agents having a low potential for extrapyramidal side effects. The novel compounds are prepared from novel intermediates of formula Image or their salts wherein R has the meanings defined above and R2 is hydrogen, lower alkyl or phenyl(lower alkyl).

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