4(or 3)-(3,4-dihydroxyphenyl)pyridines, their preparation...

Details 4(or 3)-(3,4-dihydroxyphenyl)pyridines, their preparation... 4(or 3)-(3,4-dihydroxyphenyl)pyridines, their preparation...

C - Chemistry, Metallurgy

07

D

260/296, 260/297

C07D 213/30 (2006.01)

Patent

CA 1148163

ABSTRACT OF THE DISCLOSURE 4(or 3)-(3,4-Dihydroxyphenyl)pyridine, a cardiotonic agent, is prepared by demethylating 4(or 3)-13,4-dimethoxy- phenyl)pyridine, preferably by heating with aqueous hydrogen bromide. 4(or 3)-[3,4-dihydroxyphenyl]pyridine, or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active component in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel isomeric 2-[3,4-dihydroxyphenyl]pyridine is shown for comparative purposes.

367089

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