4- or 6-substituted aldosterones, and their production and...

Details 4- or 6-substituted aldosterones, and their production and... 4- or 6-substituted aldosterones, and their production and...

C - Chemistry, Metallurgy

07

J

260/13, 195/35,

C07J 71/00 (2006.01) C12N 9/40 (2006.01) G01N 33/74 (2006.01)

Patent

CA 1227479

- 1- Abstract The invention provides a substituted aldosterone of the formula: Image (I) wherein either one of R1 and R2 is hydrogen and the other is -S(CH2)mCOR3 or -OCO(CH2)nCOR3, provided that when R1 is hydrogen, R2 is -S(CH2)mCOR3 or -OCO(CH2)nCOR3 and when R2 is hydrogen, R1 is -S(CH2)mCOR3; m being an integer from 1 to 3, n being an integer from 1 to 5 and R3 being hydroxyl, lower alkoxy or a residue of tyramine, tyrosine lower alkyl ester, histamine, histidine, 7-aminoheptanoyltyrosine lower alkyl ester or .beta.-D-galactosidase optionally iodinated, or its (18-20)-acetal 20,21-ketonide. The substituted aldo- sterones (I) are useful as the reagent in the determination of aldosterones by radioimmunoassay or enzyme immunoassay.

427792

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