4-oxa and 4-thia steroids

Details 4-oxa and 4-thia steroids 4-oxa and 4-thia steroids

C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2233966

The compounds of the present invention are those of structural formula (I) wherein X is oxygen or sulfur. Pharmaceutical compositions and methods of use of the compounds in the treatment of hyperandrogenic conditions are disclosed. In addition, the combination of the compounds with other active agents such as finasteride, minoxidil and retinoic acid or a derivative thereof is disclosed.

Les composés de cette invention sont représentés par la formule (I) dans laquelle X représente oxygène ou soufre. Sont également décrits des compositions pharmaceutiques et des procédés d'utilisation desdits composés dans le traitement des pathologies hyperandrogéniques, ainsi que la combinaison de ces mêmes composés avec d'autres agents actifs tels que le finastéride, le minoxidil et l'acide rétinoïque ou un dérivé de ce dernier.

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