C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/56 (2006.01) A61K 31/47 (2006.01) A61P 31/22 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2353634
The present invention provides a compound of formula (I) Wherein R1 is C1-7 alkyl, optionally substituted by hydroxy or NR4R5; R2 is C1-7 alkyl substituted by hydroxy or NR4R5; R3 is H, F or C1-7 alkoxy; R4 and R5 together with N are a 5- or 6-membered heterocyclic moiety having 1-3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur in which sulfur may be substituted by one (1) or two (2) oxygen atoms; and pharmaceutically acceptable salts thereof. Compounds of formula (I) of the present invention are useful as antiviral agents.
L'invention porte sur un composé de formule (I) dans laquelle: R?1¿ est C¿1-7? alkyle, facultativement substitué par hydroxy ou NR?4¿R?5¿; R?2¿ est C¿1-7? alkyle substitué par hydroxy ou bien NR?4¿R?5¿; R?3¿ est H, F ou bien C¿1-7? alkoxy; R?4¿ et R?5¿ forment ensemble et avec N des fragments hétérocycliques à 5 ou 6-éléments présentant 1 à 3 hétéroatomes sélectionnés parmi azote, oxygène et soufre, le soufre pouvant être substitué par un (1) ou deux (2) atomes d'oxygène; ainsi que sur leurs sels pharmacocompatibles. Lesdits composés de formule (I) sont utilisables comme agents antiviraux.
Schnute Mark E.
Scott Allen
Strohbach Joseph Walter
Thaisrivongs Suvit
Turner Steven Ronald
Macrae & Co.
Pharmacia & Upjohn Company
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