4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives

Details 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 243/14 (2006.01) A61K 31/5513 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2663240

The invention relates to 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and claims, which are .gamma.-secretase inhibitors and which may be useful in the treatment of Alzheimer's disease.

L'invention concerne des dérivés 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazépine de formule (I) où R1, R2, R3 et R4 sont tels que définis dans la description et dans les revendications, qui sont des inhibiteurs .gamma.-secrétase et qui peuvent être utiles dans le traitement de la maladie d'Alzheimer.

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