4-oxo-5n-piperidino-thiazolidin-2-ylidene acetic acid

Details 4-oxo-5n-piperidino-thiazolidin-2-ylidene acetic acid 4-oxo-5n-piperidino-thiazolidin-2-ylidene acetic acid

C - Chemistry, Metallurgy

07

D

260/278.4

C07D 417/04 (2006.01) C07D 277/34 (2006.01) C07D 277/38 (2006.01) C07D 277/54 (2006.01)

Patent

CA 1113471

Abstract The present invention is concerned with a new and chemically unique one-pot process for the preparation of thiazolidin-4-one-acetic acid derivatives of the general formula:- Image (I) wherein R1 is a lower alkyl radical. In this new process, the 5-bromo derivatives of the corresponding carboxylic acid alkyl esters are prepared by reaction with elementary bromine in a solvent of low polarity. The hydrogen bromide thereby formed splits the ester bond at elevated temper- atures, whereupon the 5-bromo derivatives of the free acid can be directly reacted in situ with piperidine.

319979

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