4-oxo-7-substituted hydroxy-4h-benzopyrane derivatives

Details 4-oxo-7-substituted hydroxy-4h-benzopyrane derivatives 4-oxo-7-substituted hydroxy-4h-benzopyrane derivatives

C - Chemistry, Metallurgy

07

D

260/356.1, 260/3

C07D 311/22 (2006.01) C07D 311/36 (2006.01) C07D 311/38 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1319694

D01-46373C/JK/87 ABSTRACT OF THE DISCLOSURE A benzopyran derivative represented by formula Image whsrein: R1 and R2 each represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted cyclic alkyl group, a mono- or di-lower alkylamino group, a substituted or unsubstituted cyclic amino group, a substi- tuted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group; Y1 and Y2 each represents a hydrogen atom, a lower alkyl group, a halogen atom or a trihalomethyl group; Z represents a carboxyl group, a lower alkoxy- carbonyl group, a tetrazolyl group, a hydroxyl group or -CONR3R4 wherein R3 and R4 each represents a hydrogen atom or a lower alkyl group; n represents an integer of from 1 to 6; and the bond ? between the 2- and 3-positions represents a single bond or a double bond; provided that a combination wherein Y1, Y2, and R2 each represents a hydrogen atom, R1 represents a phenyl group, n represents 1, Z represents a carboxyl group or an alkoxycarbonyl group, and the bond ? represents a double bond, and a combination wherein Y1, Y2, and R1 each repre- sents a hydrogen atom, R2 represents a phenyl group, n represents 1, Z represents a carboxyl group or an alkoxy- carbonyl group, and the bond ? represents a double bond are excluded, and pharmaceutically acceptable salts thereof are disclosed. These compounds have uricosuric activity, diuretic activity and antihypertensive activity, and are useful as pharma- ceuticals.

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