4-oxo-pyrido[2,3-d]pyrimidine derivatives, process for their...

Details 4-oxo-pyrido[2,3-d]pyrimidine derivatives, process for their... 4-oxo-pyrido[2,3-d]pyrimidine derivatives, process for their...

C - Chemistry, Metallurgy

07

D

167/219, 260/242

C07D 471/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 1260936

Abstract The present invention concerns new 4-oxo-pyrido[2,3-d]pyrimidine derivatives of the general formula I Image (I) wherein R1 respresents an unsubstituted or substituted aromatic or heteroaromatic ring, R2 a nitril group, a carboxyl group or an alkoxycarbonyl residue with up to 6 carbon atoms, R3 a straight-chained or branched alkyl group with up to 4 carbon atoms, or an amino group, and R4 represents hydrogen, an alkyl, alkoxyalkyl or a substi- tuted or unsubstituted aminoalkyl group, the pharmacologically acceptable salts thereof, as well as processes for their preparation. The compounds of the general formula I possess valuable pharma- cological properties. In particular used as calcium antagonists they exert vasospasmolytic, vasodilatory and antihypertensive acitvities. Surprisingly some of the compounds also have the effect of increasing contractility. They are therefore particu- larly suited for the treatment of vascular diseases.

493199

Affiliated with

Also associated with

Rating

4-oxo-pyrido[2,3-d]pyrimidine derivatives, process for their... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-oxo-pyrido[2,3-d]pyrimidine derivatives, process for their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-oxo-pyrido[2,3-d]pyrimidine derivatives, process for their... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1222959