4-oxy-n-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides,...

Details 4-oxy-n-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides,... 4-oxy-n-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides,...

C - Chemistry, Metallurgy

07

D

C07D 285/12 (2006.01) A61K 31/433 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2624726

The invention relates to 4-oxy-N-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides and to their physiologically acceptable salts and physiologically functional derivatives showing PPARalpha, PPARdelta and PPARgamma agonist activity. What is described are compounds of the formula (I), in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

La présente invention concerne les 4-oxy-N-[1,3,4]-thiadiazol-2-yl-benzène sulfonamides ainsi que leurs sels physiologiquement acceptables et leurs dérivés physiologiquement fonctionnels présentant une activité agoniste vis-à-vis de PPARalpha, PPARdelta et PPARgamma. L~invention concerne des composés de formule (I), les radicaux étant tels que définis, ainsi que leurs sels physiologiquement acceptables et des procédés pour leur préparation. Les composés conviennent pour le traitement et/ou la prévention des pathologies liées au métabolisme des acides gras et à l~utilisation du glucose, ainsi que des pathologies liées à la résistance à l~insuline et à la démyélinisation et d~autres maladies neurodégénératives du système nerveux central et périphérique.

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