4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and...

Details 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and... 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and...

C - Chemistry, Metallurgy

07

D

C07D 211/42 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/08 (2006.01) C07D 521/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2230931

The invention relates to novel piperidine derivatives of the general formula I (see formula I) wherein R1, R2, R3, R4, Q, W, X, Z, m and n have the meaning given in the specification. The novel piperidine derivatives can be used as renin inhibitors in the control or prevention of high blood pressure and cardiac insufficiency, as well as glaucoma, cardiac infarct, kidney insufficiency and restonosis.

Ces nouveaux dérivés de pipéridine de la formule générale (I), dans laquelle R<1>, R<2>, R<3>, R<4>, Q, X, W, Z, m et n ont la notation donnée dans la description, représentent des inhibiteurs de la rénine et peuvent être utiles pour traiter par exemple l'hypertension, ainsi que l'insuffisance cardiaque et rénale.

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