4-(penyl-piperidin-4-ylidene-methyl)-benzamide derivatives...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/06 (2006.01) A61K 31/4545 (2006.01) A61P 25/04 (2006.01) A61P 25/22 (2006.01) C07D 211/70 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2446154

Compounds of general formula I[Chemical formula should be inserted here. Please see paper copy] R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1,2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

L'invention concerne des composés de formule générale (I) dans laquelle R¿1? est choisi parmi l'un des groupes quelconque suivants: phényle, pyridinyle, pyrrolyle, thiényle, furanyle, imidazole, triazole, et pyridine N-oxyde; cahque noyau phényle R¿1? et chaque noyau hétéroaromatique R¿1? peut éventuellement et indépendamment être, en outre, substitué par 1, 2, ou 3 substituants choisis parmi les groupes à chaîne droites ou ramifiées suivants: alkyle C¿1?-C¿6?, NO¿2?, CF¿3?, alkoxy C¿1?-C¿6?, chloro, fluoro, bromo, et iodo. Les substitutions sur le noyau de phényle et sur le noyau hétéroaromatique peuvent être réalisées dans n'importe quelle position sur lesdits systèmes de noyaux; L'invention concerne également les sels pharmaceutiques acceptables de ces substituants et leurs compositions pharmaceutiques comprenant les nouveaux composés et leur utilisation thérapeutique, notamment dans le traitement de la douleur, de l'anxiété et de troubles gastro-intestinaux.

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