(4-phenyl-1,3-dioxan-cis-5-yl)acetaldehyde derivatives

Details (4-phenyl-1,3-dioxan-cis-5-yl)acetaldehyde derivatives (4-phenyl-1,3-dioxan-cis-5-yl)acetaldehyde derivatives

C - Chemistry, Metallurgy

07

D

260/351

C07D 319/04 (2006.01) C07C 59/48 (2006.01) C07C 69/732 (2006.01) C07D 407/10 (2006.01)

Patent

CA 1268772

ABSTRACT The invention concerns novel (4-phenyl-1,3-dioxan-cis- 5-yl)acetaldehyde derivatives of the formula II Image II having cis relative stereochemistry at positions 4 and 5 of the dioxane ring and wherein Ra and Rb are variously hydrogen, alkyl, halogenoalkyl, alkenyl, and optionally substituted aryl or aryl- alkyl, Rc is hydroxy, alkoxy or alkanesulphonamido; n is 1; and benzene ring B is optionally substituted phenyl. The (4-phenyl- 1,3-dioxan-cis-5-yl)acetaldehyde derivatives are useful inter- mediates in the preparation of 1,3-dioxan-5-ylalkenoic acid derivatives that antagonise one or more of the actions of thromboxane A2 (TXA2) and are of value in those disease conditions in which TXA2 is involved.

600592

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