4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/02 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) C07D 209/08 (2006.01) C07D 209/30 (2006.01) C07D 215/227 (2006.01) C07D 217/06 (2006.01) C07D 295/027 (2006.01) C07D 295/073 (2006.01) C07D 295/104 (2006.01)

Patent

CA 2395869

The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having formula (I), wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W is N or CH; R1 and R2 are independently selected from hydrogen and halogen, provided at least one of R1 and R2 is a halogen atom; X is CH2, O, S, CO, CS, SO or SO2; and Q is a group of formula (II) provided that X is not O or S when the group Q is attached via an N atom; and any of its enantiomers and acid addition salts thereof. These compounds have high affinity for D4 receptors.

La présente invention concerne des dérivés de 4-phényle-1-pipérazinyle de la formule (I) dans laquelle W est C, CH ou N (la ligne pointillée partant de W indique une liaison quand W est C, et aucune liaison quand W est N ou CH); R<1> et R<2> sont indépendamment sélectionnés dans le groupe constitué par hydrogène et halogène, à condition qu'au moins R<1> ou R<2> soit un atome d'halogène; X est CH2, O, S, CO, CS, SO ou SO2; et Q est un groupe de la formule (II) à condition que X ne soit pas O ou S quand le groupe Q est fixé par un atome N. L'invention concerne des énantiomères quelconques et sels d'addition acides desdits dérivés. Les composés de l'invention présentent une grande affinité pour les récepteurs de D4.

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