4-phenyl-4,5,6,7-tetrahydro-pyrrolo[2,3-c] pyridines,...

Details 4-phenyl-4,5,6,7-tetrahydro-pyrrolo[2,3-c] pyridines,... 4-phenyl-4,5,6,7-tetrahydro-pyrrolo[2,3-c] pyridines,...

C - Chemistry, Metallurgy

07

D

260/273, 260/246

C07D 471/04 (2006.01) C07D 207/335 (2006.01)

Patent

CA 1138864

ABSTRACT The invention relates to compounds possessing anti-depressant activity specifically to compounds of formula I Image (I) [wherein R1 represents a methyl group; R2 represents a hydrogen, chlorine or bromine atom; a formyl or acetyl group; a straight-chained or branched alkyl group having from 1 to 4 carbon atoms; a cyano or nitro group; or a group of formula -CH2A wherein A represents an alkylamino or dialkylamino group, the alkyl radical(s) of which each contains 1 or 2 carbon atoms and one alkyl radical of which is optionally substituted terminally by a hydroxy group; or A represents a 5-, 6- or 7-membered saturated nitrogen-containing ring in which the nitrogen atom is in the 1-position, the ring is optionally substituted by a hydroxy or hydroxymethyl group and, in the case of the 6-membered ring, an oxygen atom optionally occupies the 4-position as a further heteroatom); R3 represents a hydrogen, fluorine, chlorine or bromine atom or a methyl or methoxy group; and R4 represents a hydrogen atom or an alkyl group having from 1 to 3 carbon atoms] and acid addition salts thereof. The invention further provides a process for the preparation of such compounds, pharmaceutical compositions thereof and a method of treatment of the human animal body therewith.

355540

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