4-phenyl-4-oxo-butanoic acid derivatives with...

Details 4-phenyl-4-oxo-butanoic acid derivatives with... 4-phenyl-4-oxo-butanoic acid derivatives with...

C - Chemistry, Metallurgy

07

C

C07C 59/88 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) C07C 59/90 (2006.01) C07C 69/738 (2006.01) C07C 235/78 (2006.01) C07C 255/41 (2006.01) C07C 255/57 (2006.01) C07C 259/06 (2006.01) C07C 323/56 (2006.01) C07C 323/62 (2006.01)

Patent

CA 2236450

4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such an enyzme is needed. The present invention further comprises a selected class of the above mentioned 4-phenyl-4-oxo- butanoic acid derivatives, their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them.

On décrit des dérivés de l'acide 4-phényl-4-oxo-butanoïque utiles en thérapeutique dans le traitement du corps humain ou animal, et notamment en tant qu'inhibiteurs de la kynurénine-3-hydroxylase dans la prévention et/ou le traitement de maladies neurodégénératives dans lesquelles il est nécessaire d'inhiber une telle enzyme. La présente invention comprend en outre une clase sélectionnée de dérivés de l'acide 4-phényl-4-oxo-butanoïque ci-dessus mentionnés, leurs sels pharmaceutiquement acceptables, un procédé de préparation de ces dérivés, ainsi que des compositions pharmaceutiques contenant ceux-ci.

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