4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as...

Details 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as... 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as...

C - Chemistry, Metallurgy

07

D

C07D 215/48 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61P 5/24 (2006.01) A61P 15/00 (2006.01) C07D 215/20 (2006.01) C07D 215/38 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2606682

The invention relates to a 4-phenyl-5-oxo-l,4,5,6,7,8-hexahydroquinoline derivative according to Formula (I), wherein the substituents are defined as in the description, or a pharmaceutically salt thereof. The compounds of this invention are potent FSH receptor activators and may be used for treating fertility disorders in e.g. controlled ovarian hyperstimulation and IVF procedures.

L'invention concerne un dérivé de 4-phényl-5-oxo-1,4,5,6,7,8-hexahydroquinoline de formule (I). Dans cette formule, les substituants sont définis dans la description. L'invention concerne également un sel pharmaceutiquement acceptable de ces dérivés. Les composés de l'invention sont de puissants activateurs du récepteur de FSH et peuvent être utilisés pour traiter des troubles de fertilité dans des procédures IVF et dans des procédures d'hyperstimulation ovarienne contrôlée.

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