4-phenyl and 5-phenyl-1,4,5,6- tetrahydropyrimidine derivatives

Details 4-phenyl and 5-phenyl-1,4,5,6- tetrahydropyrimidine derivatives 4-phenyl and 5-phenyl-1,4,5,6- tetrahydropyrimidine derivatives

C - Chemistry, Metallurgy

07

D

260/263

C07D 239/12 (2006.01) C07D 239/14 (2006.01) C07D 239/16 (2006.01)

Patent

CA 1132565

21120 Abstract of the Disclosure Compounds represented by the formula Image (I) wherein A is H, R?- or RO?- where R is alkyl of one through six carbon atoms; X is hydrogen, fluoro, chloro, bromo, iodo, hydroxy, alkoxy of one through four carbon atoms, benzyloxy, alkyl of one through four carbon atoms, alkylthio of one through four carbon atoms, alkylsulfinyl of one through four carbon atoms, alkylsulfonyl of one through four carbon atoms or trifluoromethyl; and Y is hydrogen or is the same as X; and R1 is hydrogen or alkyl of one through four carbon atoms the phenyl substituent carrying the X and Y is at the 4- or 5-position of the tetrahydropyrimidine ring when R1 is hydrogen or is at the 5-position when R1 is alkyl; and the pharmaceutically acceptable salts thereof. These compounds are pharmaceutically useful for treating depresssion, anxiety, convulsions, centrally-induced skeletal muscle spasm and spasticity.

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