(4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and...

Details (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and... (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/451 (2006.01) C07D 211/40 (2006.01) C07D 211/42 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2467749

The invention relates to substituted piperidine piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers.

L'invention concerne des composés substitués de pipéridine, de pipérazine, de morpholine et de thiomorpholine utiles dans le traitement de la maladie d'Alzheimer, et plus spécifiquement des composés capables d'inhiber la bêta-sécrétase, une enzyme qui coupe une protéine précurseur amyloïde pour former le peptide bêta-amyloïde, un constituant majeur des plaques amyloïdes présentes dans le cerveau des personnes atteintes de la maladie d'Alzheimer.

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