C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61K 31/4523 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 407/06 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2446516
Compounds of general formula I[Chemical formula should be inserted here. Please see paper copy] R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N- oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1,2 or 3 substituents selected from straight and branched C1-C6alkyl, NO2, CF3, C1-C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.
L'invention concerne des composés de formule générale I, dans laquelle R?1¿ est choisi dans le groupe constitué par phényle, pyridinyle, thiényle, furanyle, imidazolyle, pyrrolyle, triazolyle, thiazolyle et pyridine N-oxyde; chaque cycle phényle R?1¿ et chaque cycle hétéroaromatique R?1¿ peuvent facultativement et indépendamment être substitués par 1, 2 ou 3 substituants choisis dans le groupe constitué par alkyle C¿1?-C¿6? linéaire ou ramifié, NO¿2?, CF¿3?, alcoxy C¿1?-C¿6?, chloro, fluoro, bromo et iodo. Les substitutions sur le cycle phényle et sur le cycle hétéroaromatique peuvent se produire à n'importe quel endroit sur lesdits systèmes cycliques. L'invention concerne également des sels et des compositions pharmaceutiques contenant ces nouveaux composés, ainsi que leur utilisation thérapeutique, notamment dans le traitement de la douleur, de l'anxiété et des troubles gastro-intestinaux fonctionnels.
Brown William
Griffin Andrew
Walpole Christopher
Astrazeneca Ab
Fetherstonhaugh & Co.
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