4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives...

Details 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives... 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives...

C - Chemistry, Metallurgy

07

D

C07D 211/70 (2006.01) A61K 31/445 (2006.01) A61K 31/4523 (2006.01) A61P 25/04 (2006.01) A61P 25/22 (2006.01) C07D 211/58 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2446155

Compounds of general formula I: R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprisingthe novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

L'invention concerne des composés de formule générale (I), dans laquelle R?1¿ est sélectionné parmi n'importe lequel des composés suivants : le phényle, le pyridinyle, le pyrrolyle, le thiényle, le furanyle, l'imidazolyle, le triazolyle, le thiazolyle et N-oxyde de pyridine, où chaque anneau de phényle R?1¿ et chaque anneau hétéroaromatique R?1¿ peuvent facultativement et indépendamment être substitués par des substituants 1, 2 ou 3 sélectionnés parmi C¿1-?C¿6? alkyle ramifié ou linéaire, NO¿2?, CF¿3?, C¿1?-C¿6 ?alkoxy, le chlore, le fluore, le brome et l'iode. Ladite invention concerne aussi les substitutions sur l'anneau de phényle et sur l'anneau hétéroaromatique qui peuvent avoir lieu à n'importe quelle position sur lesdits systèmes d'anneau, ainsi que des sels et des compositions pharmaceutiques contenant les nouveaux composés et leur utilisation en thérapie, notamment dans la gestion de douleurs, de l'anxiété et de troubles fonctionnels gastro-intestinaux.

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