4-phenyl-pyrimidine-2-carbonitrile derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 239/28 (2006.01) A61K 31/505 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2567845

The invention relates to 4-phenyl-pyrimidine-2-carbonitrile derivatives having the general formula (I) or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives as well as to the use thereof in the preparation of a medicament suitable for the treatment of osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.

L'invention concerne des dérivés de 4-phényle-pyrimidine-2-carbonitrile représentés par la formule générale (I) ou un sel de ceux-ci acceptables sur le plan pharmaceutique. L'invention concerne également des compositions pharmaceutiques contenant ces dérivés ainsi que l'utilisation de celles-ci dans la préparation d'un médicament destiné au traitement de l'ostéoporose, de l'athérosclérose, de troubles inflammatoires et immunitaires, tels que la polyarthrite rhumatoïde, et les douleurs chroniques telles que les douleurs neuropathiques.

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