4-phenyl-substituted tetrahydroisoquinolines and use thereof...

Details 4-phenyl-substituted tetrahydroisoquinolines and use thereof... 4-phenyl-substituted tetrahydroisoquinolines and use thereof...

C - Chemistry, Metallurgy

07

D

C07D 217/04 (2006.01) A61K 31/472 (2006.01) A61P 25/00 (2006.01) C07D 217/14 (2006.01) C07D 217/16 (2006.01) C07D 217/24 (2006.01)

Patent

CA 2389300

Provided herein are compounds of formulae IA-IF. These compounds are tetrahydroisoquinolines of structure (A) wherein R1-R8 for compounds of each of the formulae IA, IB, IC, ID, IE and IF are as described herein. Said compounds are particularly useful in the treatment of various neurological and psychiatric disorders, e.g., ADHD.

On décrit des composés de formules IA-IF. Ces composés sont des tétrahydroisoquinolines de structure (A) dans laquelle R?1¿-R?8¿ pour des composés représentés par chacune des formules IA, IB, IC, ID, IE et IF sont tels que décrits dans le descriptif. Ces composés sont tout particulièrement utiles dans le traitement de divers troubles neurologiques et psychiatriques, par exemple, le trouble d'hyperactivité avec déficit de l'attention (THADA).

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