4-phenyl-thieno-[2,3-c]- piperidine derivatives

Details 4-phenyl-thieno-[2,3-c]- piperidine derivatives 4-phenyl-thieno-[2,3-c]- piperidine derivatives

C - Chemistry, Metallurgy

07

D

260/276.1

C07D 495/04 (2006.01) C07D 333/30 (2006.01)

Patent

CA 1113095

ABSTRACT OF THE DISCLOSURE This invention relates to 4-phenyl-thieno-[2,3-c]- piperidines of formula Image I (wherein R1 is chlorine or bromine or an alkyl group; R2 is hydrogen or, when is alkyl, chlorine or bromine; or R1 and R2 together are a 3- or 4- membered alkylene chain; R is hydrogen, fluorine, chlorine or bromine or an alkyl, hydroxy or trifluoromethyl group; and R is hydrogen or an alkyl or phenylalkyl group) and acid addition salts thereof. The compounds have antidepressive properties and in particular a central nervous system stimulating activity. Processes for the preparation of the compounds, and pharmaceutical compositions containing them, are described and exemplified.

313339

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