C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/224, 260/264
C07D 237/30 (2006.01) A61K 31/50 (2006.01) C07D 237/34 (2006.01) C07D 405/00 (2006.01) C07D 491/056 (2006.01)
Patent
CA 2039258
-38- Abstract of the Disclosure: 4-Phenylphthalazine derivatives of the formula: Image wherein R1 is an alkyl or hydroxyalkyl group of 1-5 carbon atoms; R2 is a hydrogen atom or an alkyl group of 1 5 carbon atoms; or R1 and R2, when taken together, may represent an alkylene group of 2-6 carbon atoms, said group optionally containing one or more oxygen atoms; R3 and R4 are independently a hydrogen or halogen atom, an alkyl or alkoxy group of 1-4 carbon atoms, or when two of R3 are adjacently positioned, (R3)? may represent a -0-(CH2)p-0- group and/or when two of R4 are adjacently positioned, (R4)m may represent a -0-(CH2)p-0- group; R5 is a hydrogen or halogen atom, an alkyl or alkoxy group of 1-4 carbon atoms, a trifluoromethyl group or a hydroxy group, or when two of R5 are adjacently positioned, (R5)n may represent a -0-(CH2)p-0- group; p is an integer of 1-3; ? and m are independently an }nteger of 1-2; and n is an integer of 1-3, and optical isomers and pharmaceutically acceptable acid addition salts thereof.
Iwase Norimichi
Kanayama Toshiji
Morinaka Yasuhiro
Tamao Yoshikuni
Kirby Eades Gale Baker
Mitsubishi Chemical Corporation
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