C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61P 29/02 (2006.01) C07D 211/98 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2582933
The invention relates to piperidinyl compounds of Formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to an assay useful for identifying such compounds as N-type calcium channel modulators or blockers. The invention is also directed to the compounds of Formula (I) and compounds identified by the above assay, and the use of such compounds to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
L'invention concerne des composés pipéridinyle de formule (I): ou un sel, promédicament, ou solvate pharmaceutiquement acceptable correspondant, sachant que R1-R3 et Z sont tels que définis dans la description. L'invention concerne également un essai utile pour l'identification de tels composés comme agents de modulation ou de blocage de canal calcique de type N. On décrit aussi des composés de formule (I) et des composés identifiés par l'essai considéré, ainsi que l'utilisation de ces composés pour traiter, prévenir ou améliorer un trouble qui répond au bocage des canaux calciques, et en particulier ceux de type N. Les composés considérés sont utiles, en particulier pour le traitement de la douleur.
Benjamin Elfrida R.
Chen Zhengming
Sha Deyou
Tafesse Laykea
Victory Samuel F.
Euro-Celtique S.a.
Gowling Lafleur Henderson Llp
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