4-piperazinothieno [2, 3-d] pyrimidine compounds as platelet...

Details 4-piperazinothieno [2, 3-d] pyrimidine compounds as platelet... 4-piperazinothieno [2, 3-d] pyrimidine compounds as platelet...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2602538

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: (I) wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2a, Rx, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

La présente invention décrit des dérivés et des sels de qualité pharmaceutique des dérivés dont la structure est représentée par la Formule I : (I) où A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2a, Rx, R4, R5 et R6 sont tels que définis dans la description détaillée de l'invention. La présente invention décrit en outre les préparations pharmaceutiques, les méthodes de traitement, les méthodes de synthèse et les intermédiaires correspondants auxdits dérivés.

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