4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor...

Details 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor... 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) C07D 209/08 (2006.01) C07D 209/30 (2006.01)

Patent

CA 2501172

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I): wherein R1, R2, R3, R4, and R5 are as defined herein; or individual isomer, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

L'invention concerne des composés présentant généralement une affinité pour le récepteur 5-HT6 et représentés par la formule (I). Dans cette formule, R?1¿, R?2¿, R?3¿, R?4¿, et R?5¿ sont définis dans la description, ou sont des isomères individuels, des mélanges racémiques ou non racémiques d'isomères, des sels pharmaceutiquement acceptables ou des solvants pharmaceutiquement acceptables de ceux-ci. L'invention concerne également des compositions pharmaceutiques contenant de tels composés, des méthodes pour leur utilisation en tant qu'agents thérapeutiques et des méthodes pour leur préparation.

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