4-piperazinylindole derivatives with 5-ht6 receptor affinity

Details 4-piperazinylindole derivatives with 5-ht6 receptor affinity 4-piperazinylindole derivatives with 5-ht6 receptor affinity

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/496 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 209/40 (2006.01)

Patent

CA 2450245

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by formula (I), wherein R3 is SO2-Ar, Ar is aryl or heteroaryl; and R1, R2, R4 and R5 are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

La présente invention concerne des composés qui présentent de manière générale une affinité avec les récepteurs 5-HT6 correspondant à la formule (I), dans laquelle : R?3¿ est SO¿2?-Ar ; Ar est aryle ou hétéroaryle ; et R?1¿, R?2¿, R?4¿ et R?5¿ sont tels que définis dans la description ; ou des isomères individuels, des mélanges racémiques ou non racémiques d'isomères, ou leurs sels ou solvates pharmaceutiquement acceptables. L'invention concerne également les compositions pharmaceutiques comprenant de tels composés, des procédés pour leur utilisation en tant qu'agents thérapeutiques, et leurs procédés de préparation.

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