C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/46 (2006.01) A61K 31/451 (2006.01) A61K 31/4523 (2006.01) A61P 3/06 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2657069
A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11.beta.-hydroxy-steroid dehydrogenase type 1 (11 .beta.HSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g the metabolic syndrome.
L'invention concerne une nouvelle classe de composés représentés par la formule générale (I), leur utilisation thérapeutique, des compositions pharmaceutiques contenant lesdits composés, ainsi que leur utilisation dans la fabrication de médicaments. Les composés de la présente invention modulent l'activité de la 11.beta.-hydroxy-stéroïde déshydrogénase de type 1 (11 .beta.HSD1 ) et sont par conséquent utilisés dans le traitement de maladies dans lesquelles une telle modulation est bénéfique, par exemple le syndrome métabolique.
Andersen Henrik Sune
Ebdrup Soren
High Point Pharmaceuticals Llc
Smart & Biggar
LandOfFree
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