4-pyrazolyl-n-arylpyrimidin-2-amines and...

Details 4-pyrazolyl-n-arylpyrimidin-2-amines and... 4-pyrazolyl-n-arylpyrimidin-2-amines and...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 451/06 (2006.01) C07D 471/10 (2006.01) C07D 491/107 (2006.01) C07D 491/16 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2704599

The present invention provides substituted bicyclic heteroaryl compounds, 5 including, for example, 4-pyrazoIyI-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpy.TAU.imidin-2-amines that modulate the activity of kinases and are useful in the treatment of diseases related to activity of kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.formule :(1)

La présente invention concerne des composés hétéroaryles bicycliques substitués qui comprennent, par exemple les 4-pyrazolyl-N-arylpyrimidin-2-amines et 4-pyrazolyl-N-hétéroarylpyrimidin-2-amines, qui modulent l'activité des kinases et sont utiles pour le traitement de maladies associées à l'activité des kinases, y compris, par exemple, les maladies immunitaires, les troubles de la peau, les troubles myéloprolifératifs, le cancer et d'autres maladies. formule : (1)

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