4-pyridinyl-n-acyl-l-phenylalanines

Details 4-pyridinyl-n-acyl-l-phenylalanines 4-pyridinyl-n-acyl-l-phenylalanines

C - Chemistry, Metallurgy

07

D

C07D 213/64 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2392566

Compounds of Formula (I) are disclosed wherein R1-R7 are as defined in the application and which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and, therefore, are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4, such as chronic inflammatory diseases.

L'invention concerne des composés qui correspondent à la formule I dans laquelle R1-R7 sont définis dans l'application et qui ont une activité d'inhibiteurs de liaison entre VCAM-1 et les cellules exprimant VLA-4; ils sont utiles pour traiter des maladies dont les symptômes ou les dégâts sont en rapport avec la liaison de VCAM-1 aux cellules exprimant VLA-4 telles que des maladies inflammatoires chroniques.

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