C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/42 (2006.01) A61K 31/506 (2006.01) A61P 25/28 (2006.01) C07D 239/12 (2006.01) C07D 239/52 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2419030
This invention provides novel neuroprotective 4-pyrimidineamine derivatives and neuroprotective pharmaceutical compositions comprising 4-pyrimidinamines. This invention also provides methods of using these compositions to prevent ischemic cell death, particularly neuronal cell death, and reduce the likelihood of neuronal cell death in a subject due to a traumatic event. Finally, this invention provides an apparatus for administering to a subject the instant pharmaceutical compositions.
L'invention concerne des nouveaux dérivés 4-pyrimidinamines, neuroprotecteurs, ainsi que des compositions pharmaceutiques neuroprotectrices comprenant ces 4-pyrimidinamines. L'invention concerne également des procédés d'utilisation de ces compositions dans la prévention de la mort cellulaire ischémique, notamment la mort cellulaire neuronale, et dans la réduction de la possibilité de mort cellulaire neuronale chez un sujet, par suite d'un événement traumatique. Enfin, l'invention concerne un dispositif d'administration, à un sujet, des compositions pharmaceutiques décrites.
Brown Frank K.
Grant Elfrida R.
Mcmillan Michael
Morgan Ross Tina
Reitz Allen B.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Mcneil Pharmaceutical Inc.
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