4-quinolylamino-benzamide compounds

Details 4-quinolylamino-benzamide compounds 4-quinolylamino-benzamide compounds

C - Chemistry, Metallurgy

07

D

260/277.3, 260/2

C07D 401/12 (2006.01) C07D 211/56 (2006.01) C07D 215/44 (2006.01)

Patent

CA 1096870

- 1 - ABSTRACT OF THE DISCLOSURE The disclosure describes naw 4-aminoquinoline derivatives of general formula Image (IV) and their pharmaceutically acceptable acid addition salts, where X is trifluoromethyl or halogen, Z is hydrogen or a defined substituent and R is a group having one of the formulae Image (V) -NR1-A-NR2R3 (VI) and Image (VII) where R1 is hydrogen or lower alkyl, R2 is lower alkyl, R3 is lower alkyl and A is lower alkylene. The new 4- aminoquinoline derivatives show analgesic activity and, in some cases, anti-inflammatory activity.

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