4-substituted 10-cyanomethylenepyrrolo [4,3-e]-benzazepines

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/55 (2006.01)

Patent

CA 1296724

ABSTRACT OF THE DISCLOSURE: Disclosed are new 4-substituted 10-cyanomethylene- pyrrolo[4,3-e]-benzazepines of the formula (I): Image (I) where R1 is hydrogen or halogen, alkyl trifluoromethyl or alkoxy, R2 and R3 are hydrogens or halogens, R4 is hydrogen, alkyl or aralkyl where the aromatic system may be substituted by halogen, alkyl or methoxy radical and A is an amino, -NR5R6 where R5 and R6 form, together with the nitrogen atom connecting them, a 5 to 7-membered saturated ring which may contain a nitrogen or oxygen as further hetero atom, it being possible for an additional nitrogen to be substituted by alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl or cycloalkylmethyl, alkynyl and additionally by oxygen in the form of a N-oxide, or A is an amino radical -NHR7 where R7 is aminoalkyl, it being possible for the amine nitrogen to be substituted by alkyl or to be a constituent of a 5- to 7-membered saturated ring which may contain a nitrogen or oxygen as further hetero atom, it being possible for a nitrogen which is present to be substituted by alkyl. These new compounds and their physiologically tolerated acid addition salts are useful for treating psychological disturbances in patients.

567078

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