C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2395520
This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed herein are of formula (1) and pharmaceuitaclly acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, X, Y, and Z are defined herein. The invention further relates to pharmaceutical compositions and dosage forms comprising compounds of formula (1) and to methods of their use for the treatment and/or prevention of diseases such as, but not limited to, cancer.
L'invention concerne 7-aza-indoline-2-ones substitués en 4 et leur utilisation comme inhibiteurs de protéine kinase, en particulier ceux de la formule (1), ainsi que leurs sels, solvates, clathrates et promédicaments pharmaceutiquement acceptables. R¿1?, R¿2?, R¿3?, R¿4?, X, Y et Z sont définis dans le descriptif. L'invention concerne également des compositions pharmaceutiques et des formes posologiques comprenant des composés de la formule (1), ainsi que des procédés permettant de les utiliser dans le traitement et la prévention de maladies telles que le cancer, notamment.
Cui Jingrong
Hirth Klaus Peter
Liang Congxin
Mcmahon Gerald
Sun Li
Osler Hoskin & Harcourt Llp
Sugen Inc.
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