4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Details 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2293823

(see formula) The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts thereof. The compounds of formula (1) are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) and to methods of treating bacterial protozoa infections by administering the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1) and to intermediates useful in such preparation.

L'invention a trait à des composés répondant à la formule (<u>1</u>) et à leurs sels acceptables du point de vue pharmaceutique. Les composés répondant à la formule (<u>1</u>) sont des agents antibactériens susceptibles d'être employés au traitement d'infections bactériennes et à celui d'infections due à des protozoaires. L'invention concerne également des compositions pharmaceutiques renfermant ces composés ainsi que des méthodes de traitement d'infections dues à des bactéries et à des protozoaires par administration desdits composés. Elle porte, de surcroît, sur des procédés de préparation des composés répondant à la formule (<u>1</u>) et sur les intermédiaires entrant dans cette préparation.

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