4-(substituted aryl)-5-hydroxyisoquinolinone derivative

Details 4-(substituted aryl)-5-hydroxyisoquinolinone derivative 4-(substituted aryl)-5-hydroxyisoquinolinone derivative

C - Chemistry, Metallurgy

07

D

C07D 217/24 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 17/02 (2006.01) A61P 19/02 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2493234

A 4-(substituted aryl)-5-hydroxyisoquinolinone derivative having excellent poly(ADP-ribose) polymerase inhibitory activity; and a pharmacologically acceptable addition salt thereof. The 4-(substituted aryl)-5- hydroxyisoquinolinone derivative is represented by the general formula (1).

Cette invention concerne un dérivé 4-(aryl substitué)-5-hydroxyisoquinolinone présentant une excellente activité d'inhibition de la poly(ADP-ribose) polymérase et un sel pharmacologiquement acceptable de celui-ci. Le dérivé 4-(aryl substitué)-5-hydroxyisoquinolinone est représenté par la formule générale (1).

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