4-substituted benzimidazoles and their use as inhibitors of...

Details 4-substituted benzimidazoles and their use as inhibitors of... 4-substituted benzimidazoles and their use as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 235/06 (2006.01) A61K 31/4184 (2006.01) A61K 31/422 (2006.01) A61K 31/4245 (2006.01) A61P 1/04 (2006.01) C07D 235/08 (2006.01) C07D 235/12 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2508838

The invention relates to 6-substituted benzimidazoles of formula 1, in which X is O (oxygen) or NH and Y has either the meaning -CH2-Ar wherein Ar is a mono- or bicyclic aromatic residue, or Y denotes the group gp, formula (gp) wherein Z has the meaning -CHR8- or -CHR8-CHR9-. The compounds have gastric secretion inhibiting and excellent gastric and intestinal protective action properties.

L'invention a trait à des benzimidazoles substitués en position 6, représentés par la formule (I). Dans ladite formule, X représente O (oxygène) ou NH, et Y représente soit -CH¿2?-Ar, Ar étant un résidu aromatique mono ou bicyclique, ou Y représente le groupe représenté par la formule (gp), dans laquelle Z représente -CHR8- ou -CHR8-CHR9-. Les composés selon l'invention présentent une activité inhibitrice de la sécrétion gastrique, et des propriétés de protection gastrique et intestinale remarquables.

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