C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/16 (2006.01) A61K 31/52 (2006.01) C07D 473/18 (2006.01)
Patent
CA 2548753
The application relates to compounds with activity against infectious viruses. Accordingly, in one embodiment the invention provides a compound of the invention which is a compound of Formula I: (I) wherein: B is adenine, guanine cytosine, uracil, thymine, 7-deazaadenine, 7-deazaguanine, 7-deaza-8- azaguanine, 7-deaza-8-azaadenine, inosine, nebularine, nitropyrrole, nitroindole, 2-aminopurine, 2-amino-6-chloropuriine, 2,6-diaminopurine, hypoxanthine, pseudouridine, pseudocytosine, pseudoisocytosine, 5- propynylcytosine, isocytosines, isoguanine, 7-deazaguanine, 2-thiopyrimidine, 6-thioguanine, 4-thiothymine, 4-thiouracil O6 -methylguanine, N6 - methyladenine, O4-methylthymine, 5,6-dihydrothymine, 5,6-dihydroucacil, 4- methylindole, triazole, or pyrazolo[3,4-d]pyrimidine; and B is optionally substituted with one or more alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, hydroxy, or halo; and R1 is alkyl, alkenyl, alkynyl, cyano, azido, or fluoromethyl; or a pharmaceutically acceptable salt or solvate thereof.
La présente invention se rapporte à des composés présentant une activité dirigée contre des virus infectieux. En conséquence, un mode de réalisation de l'invention concerne un composé représenté par la formule (I), dans laquelle B est adénine, guanine, cytosine, uracile, thymine, 7-déazaadénine, 7-déazaguanine, 7-déaza-8-azaguanine, 7-déaza-8-azaadénine, inosine, nébularine, nitropyrrole, nitroindole, 2-aminopurine, 2-amino-6-chloropurine, 2,6-diaminopurine, hypoxanthine, pseudouridine, pseudocytosine, pseudoisocytosine, 5-propynylcytosine, isocytosine, isoguanine, 7-déazaguanine, 2-thiopyrimidine, 6-thioguanine, 4-thiothymine, 4-thiouracile, <I>O</I>?6¿-méthylguanine, <I>N</I>?6¿-méthyladénine, <I>O</I>?4¿-méthylthymine, 5,6-dihydrothymine, 5,6-dihydrouracile, 4-méthylindole, triazole ou pyrazolo[3,4-d]pyrimidine; et B est éventuellement substitué par un ou plusieurs des groupes alkyle, alcényle, alkynyle, cycloalkyle, (cycloalkyl)alkyle, hydroxy ou halo; et R?1¿ est alkyle, alcényle, alkynyle, cyano, azido ou fluorométhyle. L'invention se rapporte également à un sel ou un solvate pharmaceutiquement acceptable de ces composés.
Fardis Maria
Kim Choung U.
Gilead Sciences Inc.
Robic
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