C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/265.5
C07D 487/04 (2006.01)
Patent
CA 1149385
ABSTRACT/ABRIDGEMENT Novel 4-substituted imidazo[1,2-.alpha.]quinoxalines having the general formula Image , wherein X is -R1 or -NHR2 , wherein (1) R1 is bonded to a ring carbon by a carbon-to- carbon linkage and is an aliphatic, cycloaliphatic, substituted phenyl, fused bicyclic aryl; or monocyclic aryl-substituted aliphatic; and (2) R2 is a radical bonded to a nitrogen by a carbon to nitrogen linkage; said radical being selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl or a monocyclic aryl-substituted aliphatic group; and pharmaceutically acceptable salts thereof are disclosed which have several uses such as immunosuppressants, antifungal agents and/or as anti-inflamatory agents. As disclosed are certain 1-(2-acylaminophenyl)imidazoles useful in the preparation of said 4-substituted imidazo [1,2-.alpha.]quinoxalines and the method of preparing the 4-substituted imidazo[1,2-.alpha.]quinoxalines from said 1-(2-acylaminophenyl)imidazoles by use of a cyclizing agent, e.g. phosphorous oxychloride.
293972
Luber Edward J.
Warner Paul L.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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