4-substituted piperidine analogs and their use as subtype...

Details 4-substituted piperidine analogs and their use as subtype... 4-substituted piperidine analogs and their use as subtype...

C - Chemistry, Metallurgy

07

D

C07D 211/14 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 211/28 (2006.01) C07D 211/30 (2006.01) C07D 211/38 (2006.01) C07D 211/40 (2006.01) C07D 211/42 (2006.01) C07D 211/44 (2006.01) C07D 211/46 (2006.01) C07D 211/48 (2006.01) C07D 211/54 (2006.01) C07D 211/58 (2006.01) C07D 211/64 (2006.01) C07D 211/70 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405

Patent

CA 2240275

Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.

Cette invention concerne de nouveaux analogues de pipéridine à substitution en position 4, des compositions pharmaceutiques contenant ces derniers ainsi que le procédé d'utilisation d'analogues de pipéridine à substitution en position 4 en tant qu'antagonistes sélectivement actifs contre les sous-types du récepteur de N-méthyl-D-aspartate (NMDA) pour traiter des états pathologiques tels que l'attaque, l'ischémie cérébrale, le traumatisme du système nerveux central, l'hypoglycémie, la psychose, l'anxiété, les maux de tête migraineux, le glaucome, la rétinite à cytomégalovirus, la perte des cheveux induite par les antibiotiques à base d'aminosides, les convulsions, la douleur chronique, la tolérance aux opioïdes ou l'arrêt des opioïdes, l'incontinence urinaire ou les maladies neurodégénératives telles que le lathyrisme, la maladie d'Alzheimer, la maladie de Parkinson et la maladie de Huntington.

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