4-substituted piperidine derivatives useful as neurokinin...

Details 4-substituted piperidine derivatives useful as neurokinin... 4-substituted piperidine derivatives useful as neurokinin...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/00 (2006.01) C07D 413/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2166800

Compounds of formula (I) wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula (I) and intermediates.

L'invention concerne des composés de la formule (I) dans laquelle G, J, L, M, m et D ont n'importe laquelle des significations données dans le descriptif de l'invention, leurs N &cir& _-oxydes et leurs sels pharmaceutiquement acceptables sont des antagonistes non peptidiques de la neurokinine A et sont utiles dans le traitement de l'asthme, etc. L'invention concerne également des compositions pharmaceutiques, les procédés de préparation des composés de la formule (I) et leurs intermédiaires.

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