4-substituted thiazole oxamic acids and salts and esters...

Details 4-substituted thiazole oxamic acids and salts and esters... 4-substituted thiazole oxamic acids and salts and esters...

C - Chemistry, Metallurgy

07

D

167/208, 260/302

C07D 277/46 (2006.01) A61K 31/395 (2006.01) C07D 277/40 (2006.01) C07D 417/02 (2006.01)

Patent

CA 1246071

- A B S T R A C T 4-Substituted thiazole oxamic acids and esters and salts thereof. Compounds of general formula Image [wherein R1 is hydrogen or alkyl; R2 is hydrogen, methyl or carboxyl; and A is pyridyl, benzodioxanyl or the group Image (in which R3, R4 and R5 independently represent hydrogen, halogen, hydroxy, alkoxy, alkyl, alkoxycarbonyl, dialkylamino, carboxamido, nitro or cyano, or one of R3, R4 and R5 is mor- pholino, piperidino, hydroxypiperidino or phenyl and the others are as defined above] and salts thereof. The com- pounds exhibit an antiallergic activity and may be readily administered orally in low doses. Processes for the prepa- ration of the compounds and their use in pharmaceutical com- positions are described and exemplified.

330575

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